BMC Complementary Medicine and Therapies (2024)

Camel milk ameliorates steatohepatitis, insulin resistance and lipid peroxidation in experimental non-alcoholic fatty liver disease

Camel milk (CM) is gaining increasing recognition due to its beneficial effects in the control and prevention of multiple health problems. The current study aimed to investigate the effects of CM on the hepati...

Authors: Aida A Korish and Maha M Arafah

Citation: BMC Complementary and Alternative Medicine 2013 13:264

Content type: Research article Published on: 13 October 2013

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The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study

Despite the high antioxidant potential of grape seed extract (GSE), very limited studies have investigated its effect on non-alcoholic fatty liver disease (NAFLD). Therefore, this study was conducted with the ...

Authors: Parisa Ghanbari, Davoud Raiesi, Roghayeh Alboebadi, Ahmad Zarejavid, Mostafa Dianati, Hamidreza Razmi and Hadi Bazyar

Citation: BMC Complementary Medicine and Therapies 2024 24:192

Content type: Research Published on: 16 May 2024

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Probiotic mixture improves fatty liver disease by virtue of its action on lipid profiles, leptin, and inflammatory biomarkers

A high fat diet has an essential role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). This condition is characterized by hepatic fat accumulation (steatosis) and is associated with obesity, d...

Authors: Hessah Mohammed Al-muzafar and Kamal Adel Amin

Citation: BMC Complementary and Alternative Medicine 2017 17:43

Content type: Research article Published on: 13 January 2017

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The effect of Oenothera biennis (Evening primrose) oil on inflammatory diseases: a systematic review of clinical trials

Evening primrose oil (EPO), extracted from the seeds of Oenothera biennis, has gained attention for its therapeutic effects in various inflammatory conditions.

Authors: Melika Sharifi, Nasim Nourani, Sarvin Sanaie and Sanaz Hamedeyazdan

Citation: BMC Complementary Medicine and Therapies 2024 24:89

Content type: Research Published on: 15 February 2024

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Authors: Carolyn Ee, Sharmala Thuraisingam, Marie Pirotta, Simon French, Charlie Xue, Helena Teede, Agnete E. Kristoffersen, Fuschia Sirois, Trine Stub, Jennifer Engler, Stefanie Joos, Corina Güthlin, Jennifer Felenda, Christiane Beckmann, Florian Stintzing, Roni Evans…

Citation: BMC Complementary and Alternative Medicine 2017 17(Suppl 1):317

Content type: Meeting abstracts Published on: 30 June 2017

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Honey and its nutritional and anti-inflammatory value

Inflammation is the main key role in developing chronic diseases including cancer, cardiovascular diseases, diabetes, arthritis, and neurodegenerative diseases which possess a huge challenge for treatment. Wit...

Authors: Yazan Ranneh, Abdah Md Akim, Hasiah Ab. Hamid, Huzwah Khazaai, Abdulmannan Fadel, Zainul Amiruddin Zakaria, Mohammed Albujja and Mohd Fadzelly Abu Bakar

Citation: BMC Complementary Medicine and Therapies 2021 21:30

Content type: Review Published on: 14 January 2021

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Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L.

Cholestasis is an important predisposing factor for hepatocyte damage, liver fibrosis, primary biliary cirrhosis, and even liver failure. Silybum marianum L. (SM) plant is used in teas or eaten in some countries ...

Authors: Maha B. Salem, Dina Mostafa Mohammed, Olfat A. Hammam and Mohamed Elzallat

Citation: BMC Complementary Medicine and Therapies 2024 24:51

Content type: Research Published on: 23 January 2024

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Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study

Vitamin D has an established role in female reproduction. There is also evidence for an association between vitamin D levels and menstrual problems such as premenstrual syndrome (PMS) and dysmenorrhea. Curcumi...

Authors: Leyla Arabnezhad, Mahtab Mohammadifard, Ladan Rahmani, Zahra Majidi, Gordon A. Ferns and Afsane Bahrami

Citation: BMC Complementary Medicine and Therapies 2022 22:19

Content type: Research Published on: 22 January 2022

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Effects of Spirulina supplementation in patients with ulcerative colitis: a double-blind, placebo-controlled randomized trial

We conducted a randomized placebo-controlled trial to assess the efficacy of Spirulina (SP) supplementation on disease activity, health-related quality of life, antioxidant status, and serum pentraxin 3 (PTX-3...

Authors: Sajjad Moradi, Reza Bagheri, Parsa Amirian, Mahsa Zarpoosh, Neda Cheraghloo, Alexei Wong, Mehdi Zobeiri and Mohammad Hassan Entezari

Citation: BMC Complementary Medicine and Therapies 2024 24:109

Content type: Research Published on: 29 February 2024

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Phytoconstituent analysis, anti-inflammatory, antimicrobial and anticancer effects of nano encapsulated Convolvulus arvensis L. extracts

The Convolvulus genus is distributed all over the world and has a long history in traditional medicine. As nanotechnology expands its reach into areas like drug delivery and biomedicine, this study intends to ass...

Authors: Ezzat E. A. Osman, Mohamed A. Shemis, El-Sayed S. Abdel-Hameed, Abdullah E. Gouda, Hanem Hassan, Nahla Atef and Samah Mamdouh

Citation: BMC Complementary Medicine and Therapies 2024 24:122

Content type: Research Published on: 14 March 2024

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Supplementation of Syzygium cumini seed powder prevented obesity, glucose intolerance, hyperlipidemia and oxidative stress in high carbohydrate high fat diet induced obese rats

Obesity and related complications have now became epidemic both in developed and developing countries. Cafeteria type diet mainly composed of high fat high carbohydrate components which plays a significant rol...

Authors: Anayt Ulla, Md Ashraful Alam, Biswajit Sikder, Farzana Akter Sumi, Md Mizanur Rahman, Zaki Farhad Habib, Mostafe Khalid Mohammed, Nusrat Subhan, Hemayet Hossain and Hasan Mahmud Reza

Citation: BMC Complementary and Alternative Medicine 2017 17:289

Content type: Research article Published on: 2 June 2017

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Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats

Hepatocellular carcinoma (HCC) accounts for major cancer-related deaths despite current advanced therapies. Treatment and prognosis of HCC is better in patients with preserved liver function. Many natural prod...

Authors: Fazal Khan, Tariq Jamal Khan, Gauthaman Kalamegam, Peter Natesan Pushparaj, Adeel Chaudhary, Adel Abuzenadah, Taha Kumosani, Elie Barbour and Mohammed Al-Qahtani

Citation: BMC Complementary and Alternative Medicine 2017 17:418

Content type: Research article Published on: 22 August 2017

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Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study

Cystic fibrosis (CF) leads to advanced lung disease despite aggressive care. Persistent inflammation and oxidative stress contribute to exacerbations and disease progression. Flaxseed (FS), a dietary botanical...

Authors: Jason B Turowski, Ralph A Pietrofesa, John A Lawson, Melpo Christofidou-Solomidou and Denis Hadjiliadis

Citation: BMC Complementary and Alternative Medicine 2015 15:148

Content type: Research article Published on: 13 May 2015

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Isolation and structure elucidation of the compounds from Teucrium hyrcanicum L. and the investigation of cytotoxicity, antioxidant activity, and protective effect on hydrogen peroxide-induced oxidative stress

Teucrium hyrcanicum L. (family Lamiaceae) is widely distributed in the North and Northwest of Iran. It has been used in the form of tea, tonic, and tincture for the treatment of various diseases such as cough, rh...

Authors: Saeed Ghasemi, Mehdi Evazalipour, Nastaran Peyghanbari, Ehsan Zamani, Peter Bellstedt, Mahan Molaee, Diba Eghbali Koohi and Fatemeh Yousefbeyk

Citation: BMC Complementary Medicine and Therapies 2023 23:447

Content type: Research Published on: 12 December 2023

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Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

The health benefits of botanicals is linked to their phytochemicals that often exert pleiotropic effects via targeting multiple molecular signaling pathways such as the peroxisome proliferator-activated recept...

Authors: Mebrahtom Gebrelibanos Hiben, Laura de Haan, Bert Spenkelink, Sebastiaan Wesseling, Jacques Vervoort and Ivonne M. C. M. Rietjens

Citation: BMC Complementary Medicine and Therapies 2020 20:80

Content type: Research article Published on: 12 March 2020

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Bioactivity of arid region honey: an in vitro study

Antioxidant and anti-inflammatory properties of honey have been largely recognized by various studies. Almost all of the potential benefits are associated with polyphenol content. Honey varieties from the arid...

Authors: Serene Hilary, Hosam Habib, Usama Souka, Wissam Ibrahim and Carine Platat

Citation: BMC Complementary and Alternative Medicine 2017 17:177

Content type: Research article Published on: 29 March 2017

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Evaluation of antioxidant and anticancer properties of the seed extracts of Syzygium fruticosum Roxb. growing in Rajshahi, Bangladesh

The use of plants and their derived substances increases day by day for the discovery of therapeutic agents owing to their versatile applications. Current research is directed towards finding naturally-occurri...

Authors: Shafiqul Islam, Samima Nasrin, Muhammad Ali Khan, ASM Sakhawat Hossain, Farhadul Islam, Proma Khandokhar, M Nurul Haque Mollah, Mamunur Rashid, Golam Sadik, Md Aziz Abdur Rahman and AHM Khurshid Alam

Citation: BMC Complementary and Alternative Medicine 2013 13:142

Content type: Research article Published on: 22 June 2013

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Nigella Sativa reverses osteoporosis in ovariectomized rats

Osteoporosis poses a significant public health issue. It is a skeletal disorder characterized by compromised bone strength that predisposes to increased risk of fracture. There is a direct relationship between...

Authors: Ansam Aly Seif

Citation: BMC Complementary and Alternative Medicine 2014 14:22

Content type: Research article Published on: 14 January 2014

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Genus Curcuma: chemical and ethnopharmacological role in aging process

Aging or senescence is part of human life development with many effects on the physical, mental, and physiological aspects which may lead to age-related deterioration in many organs. GenusCurcumafamily Zingiera...

Authors: Esraa A. Elhawary, Ashaimaa Y. Moussa and Abdel Nasser B. Singab

Citation: BMC Complementary Medicine and Therapies 2024 24:31

Content type: Review Published on: 11 January 2024

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The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Liver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. The present study was d...

Authors: Madeha N. Al-Seeni, Haddad A. El Rabey, Mazin A. Zamzami and Abeer M. Alnefayee

Citation: BMC Complementary and Alternative Medicine 2016 16:438

Content type: Research article Published on: 4 November 2016

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A 12-week evaluation of annatto tocotrienol supplementation for postmenopausal women: safety, quality of life, body composition, physical activity, and nutrient intake

Evidence suggests that tocotrienols may benefit bone health in osteopenic women. However, their safety in this population has never been investigated. This study was to evaluate the safety of a 12-week supplem...

Authors: Chwan-Li Shen, Shu Wang, Shengping Yang, Michael D. Tomison, Mehrnaz Abbasi, Lei Hao, Sheyenne Scott, Md Shahjalal Khan, Amanda W. Romero, Carol K. Felton and Huanbiao Mo

Citation: BMC Complementary and Alternative Medicine 2018 18:198

Content type: Research article Published on: 28 June 2018

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Authors: Miriam Ortiz, Katharina Schnabel, Michael Teut, Gabriele Rotter, Sylvia Binting, Margit Cree, Fabian Lotz, Ralf Suhr, Benno Brinkhaus, Mohammad M. Parvizi, Farhad Handjani, Mohammad M. Zarshenas, Mahmood R. Moein, Majid Nimrouzi, Gholamreza Hatam, Jafar Hasanzadeh…

Citation: BMC Complementary and Alternative Medicine 2017 17(Suppl 1):333

Content type: Meeting abstracts Published on: 30 June 2017

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A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women

Nigella sativa (NS) oil has been found to have advantageous benefits in the management of inflammation and obesity. This study investigated the effect of NS supplementation on blood mRNA expressions and serum lev...

Authors: Elham Razmpoosh, Sara Safi, Mahta Mazaheri, Saman Khalesi, Majid Nazari, Parvin Mirmiran and Azadeh Nadjarzadeh

Citation: BMC Complementary Medicine and Therapies 2024 24:22

Content type: Research Published on: 5 January 2024

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Opuntia cladode powders inhibit adipogenesis in 3 T3-F442A adipocytes and a high-fat-diet rat model by modifying metabolic parameters and favouring faecal fat excretion

Obesity is a major public health concern worldwide. A sedentary life and a nutritional transition to processed foods and high-calorie diets are contributing factors to obesity. The demand for nutraceutical foo...

Authors: Cécile Héliès-Toussaint, Edwin Fouché, Nathalie Naud, Florence Blas-Y-Estrada, Maria del Socorro Santos-Diaz, Anne Nègre-Salvayre, Ana Paulina Barba de la Rosa and Françoise Guéraud

Citation: BMC Complementary Medicine and Therapies 2020 20:33

Content type: Research article Published on: 5 February 2020

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Solid state fermentation process with Aspergillus kawachii enhances the cancer-suppressive potential of silkworm larva in hepatocellular carcinoma cells

Mulberry silkworm larvae (Bombyx mori) are known as the oldest resource of food and traditional medicine. Although silkworm larvae have been reported to treat various chronic diseases, the effect of fermentation ...

Authors: Hyun-Dong Cho, Hye-Ji Min, Yeong-Seon Won, Hee-Young Ahn, Young-Su Cho and Kwon-Il Seo

Citation: BMC Complementary and Alternative Medicine 2019 19:241

Content type: Research article Published on: 5 September 2019

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Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice

The endoplasmic reticulum (ER) plays a pivotal role in maintaining cellular metabolic homeostasis. ER stress refers to the accumulation of misfolded proteins, which can trigger an unfolded protein response for...

Authors: Hyun Ju Kim and Mijeong Kim

Citation: BMC Complementary Medicine and Therapies 2023 23:141

Content type: Research Published on: 3 May 2023

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The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells

Osteoarthritis (OA) is the most common form of arthritis, affecting millions of people worldwide and characterised by joint pain and inflammation. It is a complex disease involving inflammatory factors and aff...

Authors: Sybille Brochard, Julien Pontin, Benoit Bernay, Karim Boumediene, Thierry Conrozier and Catherine Baugé

Citation: BMC Complementary Medicine and Therapies 2021 21:261

Content type: Research Published on: 14 October 2021

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Athrixia phylicoides tea infusion (bushman tea) improves adipokine balance, glucose homeostasis and lipid parameters in a diet-induced metabolic syndrome rat model

Central obesity and insulin resistance are associated with metabolic syndrome (MetS) which is aggravated by diet and sedentary lifestyle. Athrixia phylicoides (AP) is reported by rural communities to have medicin...

Authors: Madigoahle A. M. Mokwena, Godwill Azeh Engwa, Benedicta N. Nkeh-Chungag and Constance R. Sewani-Rusike

Citation: BMC Complementary Medicine and Therapies 2021 21:292

Content type: Research Published on: 29 November 2021

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Effect of camel milk on lipid profile among patients with diabetes: a systematic review, meta-analysis, and meta-regression of randomized controlled trials

The effects of camel milk (CM) intake on lipid profile among patients with diabetes remain controversial. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to calculate the ...

Authors: Narmin Khalid, Dana N. Abdelrahim, Nivine Hanach, Refat AlKurd, Moien Khan, Lana Mahrous, Hadia Radwan, Farah Naja, Mohamed Madkour, Khaled Obaideen, Husam Khraiwesh and MoezAlIslam Faris

Citation: BMC Complementary Medicine and Therapies 2023 23:438

Content type: Research Published on: 4 December 2023

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Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials

The results from clinical trials have revealed that the effects of resveratrol supplementation on bone mineral density (BMD) and bone biomarkers are inconsistent. Our objective was to determine the effects of ...

Authors: Qiangqiang Li, Guangpu Yang, Hongtao Xu, Shaowen Tang and Wayne Yuk-wai Lee

Citation: BMC Complementary Medicine and Therapies 2021 21:214

Content type: Research article Published on: 22 August 2021

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Bioassay-guided isolation of active anti-adipogenic compound from royal jelly and the study of possible mechanisms

Royal jelly (RJ) has been used traditionally for dietary, cosmetic and health purposes for a long time in different parts of the world. Scientific studies have also shown its numerous health-promoting properti...

Authors: Prakash Raj Pandeya, Ramakanta Lamichhane, Kyung-Hee Lee, Se-Gun Kim, Dae-Ho Lee, Hyeong-Kyu Lee and Hyun-Ju Jung

Citation: BMC Complementary and Alternative Medicine 2019 19:33

Content type: Research article Published on: 29 January 2019

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Research protocol: effect of natural S-equol on blood pressure and vascular function- a six-month randomized controlled trial among equol non-producers of postmenopausal women with prehypertension or untreated stage 1 hypertension

Although higher habitual soy intake is associated with lower blood pressure (BP) and stroke incidence, clinical trials using soy protein or isoflavones on cardiovascular risks yielded inconsistent results. The...

Authors: Zhao-min Liu, Suzanne C. Ho, Yu-ming Chen, Yao Jie Xie, Zhi-guan Huang and Wen-hua Ling

Citation: BMC Complementary and Alternative Medicine 2016 16:89

Content type: Study protocol Published on: 1 March 2016

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